FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T07T08T09T11T15T17T20
Z44856621 0.929 0.875 4 0.87 0.82 0.89 0.93
Z44856621 0.886 0.860 5 0.84 0.89 0.85 0.88 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44856621 T20
native IFP available
T20
selection_import_t20
0.929 1.000 0.796 native_similarity final_rank_score -15.873 -0.571051 11 3 Pose
Z44856621 T03
native IFP available
T03
selection_import_t03
0.886 1.000 0.675 native_similarity final_rank_score -28.4321 -0.799558 22 3 Pose
Z44856621 T17
native IFP available
T17
selection_import_t17
0.886 1.000 0.675 native_similarity final_rank_score -24.7951 -0.828298 21 9 Pose
Z44856621 T09
native IFP available
T09
selection_import_t09
0.877 1.000 0.650 native_similarity final_rank_score -26.4916 -0.764681 18 2 Pose
Z44856621 T07
native IFP available
T07
selection_import_t07
0.870 1.000 0.628 native_similarity final_rank_score -26.5386 -0.902398 18 2 Pose
Z44856621 T11
native IFP available
T11
selection_import_t11
0.853 1.000 0.579 native_similarity final_rank_score -19.6982 -0.699678 22 3 Pose
Z44856621 T08
native IFP available
T08
selection_import_t08
0.847 1.000 0.562 native_similarity final_rank_score -33.2402 -0.938775 16 6 Pose
Z44856621 T02
native IFP available
T02
selection_import_t02
0.838 1.000 0.539 native_similarity final_rank_score -25.1457 -0.756025 19 2 Pose
Z44856621 T15
native IFP available
T15
selection_import_t15
0.816 1.000 0.474 native_similarity final_rank_score -26.832 -0.715677 18 8 Pose