FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T06T07T09T10T13T21T22
Z44852102 0.922 0.836 7 0.75 0.82 0.82 0.79 0.83 0.92 0.92
Z44852102 0.891 0.891 1 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44852102 T21
native IFP available
T21
selection_import_t21
0.922 1.000 0.777 native_similarity final_rank_score -22.6591 -1.07859 15 12 Pose
Z44852102 T22
native IFP available
T22
selection_import_t22
0.919 1.000 0.770 native_similarity final_rank_score -30.1316 -1.24966 22 10 Pose
Z44852102 T10
native IFP available
T10
selection_import_t10
0.891 1.000 0.687 native_similarity final_rank_score -19.0549 -1.05379 16 11 Pose
Z44852102 T13
native IFP available
T13
selection_import_t13
0.826 1.000 0.502 native_similarity final_rank_score -28.7142 -1.22049 14 11 Pose
Z44852102 T07
native IFP available
T07
selection_import_t07
0.824 1.000 0.498 native_similarity final_rank_score -34.8563 -1.34336 14 7 Pose
Z44852102 T06
native IFP available
T06
selection_import_t06
0.816 1.000 0.475 native_similarity final_rank_score -25.2524 -1.06649 17 4 Pose
Z44852102 T09
native IFP available
T09
selection_import_t09
0.791 1.000 0.403 native_similarity final_rank_score -24.4025 -1.10632 14 5 Pose
Z44852102 T03
native IFP available
T03
selection_import_t03
0.750 1.000 0.287 native_similarity final_rank_score -32.5594 -1.15832 10 7 Pose