FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T13T20
Z44851669 0.893 0.893 1 0.89
Z44851669 0.829 0.807 2 0.83 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44851669 T10
native IFP available
T10
selection_import_t10
0.893 1.000 0.695 native_similarity final_rank_score -19.9305 -1.18716 15 12 Pose
Z44851669 T13
native IFP available
T13
selection_import_t13
0.829 1.000 0.512 native_similarity final_rank_score -23.6512 -1.30879 13 9 Pose
Z44851669 T20
native IFP available
T20
selection_import_t20
0.786 1.000 0.388 native_similarity final_rank_score -19.7377 -0.940081 7 7 Pose