FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 19 best compound-target hits listed 19 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T04T06T07T08T09T10T11T12T13T15T16T17T18T19T20T21T22
Z44831334 0.917 0.871 6 0.86 0.92 0.76 0.87 0.92 0.90
Z44831334 0.912 0.875 5 0.85 0.90 0.82 0.91 0.89
Z44831334 0.906 0.812 4 0.85 0.91 0.77 0.72
Z44831334 0.898 0.834 4 0.78 0.90 0.86 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44831334 T08
native IFP available
T08
selection_import_t08
0.917 1.000 0.763 native_similarity final_rank_score -35.075 -1.26163 17 9 Pose
Z44831334 T21
native IFP available
T21
selection_import_t21
0.915 1.000 0.758 native_similarity final_rank_score -23.3779 -0.950247 16 10 Pose
Z44831334 T17
native IFP available
T17
selection_import_t17
0.912 1.000 0.750 native_similarity final_rank_score -20.405 -0.964617 18 10 Pose
Z44831334 T10
native IFP available
T10
selection_import_t10
0.906 1.000 0.731 native_similarity final_rank_score -34.1592 -1.10593 14 9 Pose
Z44831334 T11
native IFP available
T11
selection_import_t11
0.898 1.000 0.708 native_similarity final_rank_score -24.9403 -1.0118 16 5 Pose
Z44831334 T06
native IFP available
T06
selection_import_t06
0.897 1.000 0.707 native_similarity final_rank_score -16.3487 -0.957481 21 3 Pose
Z44831334 T22
native IFP available
T22
selection_import_t22
0.897 1.000 0.705 native_similarity final_rank_score -32.8613 -1.30875 25 14 Pose
Z44831334 T20
native IFP available
T20
selection_import_t20
0.894 1.000 0.696 native_similarity final_rank_score -17.0873 -0.786086 12 8 Pose
Z44831334 T12
native IFP available
T12
selection_import_t12
0.875 1.000 0.643 native_similarity final_rank_score -28.1942 -1.11086 18 10 Pose
Z44831334 T13
native IFP available
T13
selection_import_t13
0.865 1.000 0.613 native_similarity final_rank_score -29.1957 -1.03516 16 11 Pose
Z44831334 T07
native IFP available
T07
selection_import_t07
0.863 1.000 0.608 native_similarity final_rank_score -41.7041 -1.2438 16 5 Pose
Z44831334 T04
native IFP available
T04
selection_import_t04
0.855 1.000 0.585 native_similarity final_rank_score -15.3644 -0.880881 14 6 Pose
Z44831334 T01
native IFP available
T01
selection_import_t01
0.855 1.000 0.584 native_similarity final_rank_score -26.1079 -0.912602 18 5 Pose
Z44831334 T16
native IFP available
T16
selection_import_t16
0.815 1.000 0.472 native_similarity final_rank_score -23.7177 -0.830657 16 4 Pose
Z44831334 T18
native IFP available
T18
selection_import_t18
0.789 1.000 0.397 native_similarity final_rank_score -18.9574 -0.932671 15 7 Pose
Z44831334 T03
native IFP available
T03
selection_import_t03
0.784 1.000 0.384 native_similarity final_rank_score -24.6273 -1.03708 13 8 Pose
Z44831334 T15
native IFP available
T15
selection_import_t15
0.771 1.000 0.345 native_similarity final_rank_score -28.0766 -0.86674 15 8 Pose
Z44831334 T09
native IFP available
T09
selection_import_t09
0.762 1.000 0.320 native_similarity final_rank_score -21.2275 -0.951939 17 6 Pose
Z44831334 T19
native IFP available
T19
selection_import_t19
0.718 1.000 0.195 native_similarity final_rank_score -32.6137 -1.20186 20 5 Pose