FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T16T17T22
Z31413736 0.929 0.827 4 0.93 0.73 0.76 0.90

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31413736 T10
native IFP available
T10
selection_import_t10
0.929 1.000 0.798 native_similarity final_rank_score -19.9183 -0.986819 16 14 Pose
Z31413736 T22
native IFP available
T22
selection_import_t22
0.896 1.000 0.703 native_similarity final_rank_score -26.7416 -1.4208 21 11 Pose
Z31413736 T17
native IFP available
T17
selection_import_t17
0.756 1.000 0.302 native_similarity final_rank_score -20.7072 -0.977976 17 7 Pose
Z31413736 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -22.6809 -1.00117 13 7 Pose