FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T08T11T12T15
Z30217191 0.915 0.864 2 0.81 0.92
Z30217191 0.888 0.888 1 0.89
Z30217191 0.834 0.834 1 0.83
Z30217191 0.786 0.786 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30217191 T12
native IFP available
T12
selection_import_t12
0.915 1.000 0.757 native_similarity final_rank_score -24.935 -1.00399 16 11 Pose
Z30217191 T11
native IFP available
T11
selection_import_t11
0.888 1.000 0.680 native_similarity final_rank_score -22.0785 -0.880266 17 5 Pose
Z30217191 T04
native IFP available
T04
selection_import_t04
0.834 1.000 0.525 native_similarity final_rank_score -22.8265 -0.887721 14 5 Pose
Z30217191 T08
native IFP available
T08
selection_import_t08
0.813 1.000 0.465 native_similarity final_rank_score -31.4886 -1.14926 15 7 Pose
Z30217191 T15
native IFP available
T15
selection_import_t15
0.786 1.000 0.388 native_similarity final_rank_score -24.5425 -0.864303 16 6 Pose