FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T09T11T12T14T18
Z28654534 0.898 0.850 7 0.83 0.86 0.85 0.90 0.85 0.86 0.80
Z28654534 0.806 0.797 2 0.81 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z28654534 T11
native IFP available
T11
selection_import_t11
0.898 1.000 0.708 native_similarity final_rank_score -28.2825 -0.877557 16 5 Pose
Z28654534 T14
native IFP available
T14
selection_import_t14
0.860 1.000 0.600 native_similarity final_rank_score -27.6357 -0.717146 18 5 Pose
Z28654534 T05
native IFP available
T05
selection_import_t05
0.859 1.000 0.599 native_similarity final_rank_score -36.7604 -0.844876 12 7 Pose
Z28654534 T09
native IFP available
T09
selection_import_t09
0.849 1.000 0.569 native_similarity final_rank_score -32.8408 -0.827611 17 4 Pose
Z28654534 T12
native IFP available
T12
selection_import_t12
0.845 1.000 0.558 native_similarity final_rank_score -31.3226 -0.814606 14 10 Pose
Z28654534 T03
native IFP available
T03
selection_import_t03
0.834 1.000 0.525 native_similarity final_rank_score -27.3947 -0.806953 16 5 Pose
Z28654534 T01
native IFP available
T01
selection_import_t01
0.806 1.000 0.446 native_similarity final_rank_score -26.8387 -0.819835 18 6 Pose
Z28654534 T18
native IFP available
T18
selection_import_t18
0.804 1.000 0.441 native_similarity final_rank_score -20.9968 -0.633197 16 7 Pose
Z28654534 T02
native IFP available
T02
selection_import_t02
0.788 1.000 0.393 native_similarity final_rank_score -28.1292 -0.845742 15 7 Pose