FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T04T11T12T15T18T20T22
Z27739534 0.917 0.836 7 0.82 0.79 0.92 0.88 0.78 0.79 0.87
Z27739534 0.771 0.771 1 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z27739534 T11
native IFP available
T11
selection_import_t11
0.917 1.000 0.763 native_similarity final_rank_score -22.2107 -0.909128 15 4 Pose
Z27739534 T12
native IFP available
T12
selection_import_t12
0.884 1.000 0.667 native_similarity final_rank_score -26.8145 -1.03441 16 12 Pose
Z27739534 T22
native IFP available
T22
selection_import_t22
0.871 1.000 0.632 native_similarity final_rank_score -28.1956 -1.12997 16 13 Pose
Z27739534 T01
native IFP available
T01
selection_import_t01
0.820 1.000 0.487 native_similarity final_rank_score -25.1809 -0.916314 16 4 Pose
Z27739534 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -18.3039 -0.729748 11 6 Pose
Z27739534 T04
native IFP available
T04
selection_import_t04
0.788 1.000 0.394 native_similarity final_rank_score -25.2892 -0.911602 12 2 Pose
Z27739534 T18
native IFP available
T18
selection_import_t18
0.777 1.000 0.362 native_similarity final_rank_score -17.3091 -0.734575 13 2 Pose
Z27739534 T15
native IFP available
T15
selection_import_t15
0.771 1.000 0.345 native_similarity final_rank_score -20.803 -0.831015 15 4 Pose