FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 13 best compound-target hits listed 13 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T04T05T06T08T09T14T15T16T17T18T20
Z27504791 0.887 0.817 6 0.89 0.84 0.85 0.78 0.76 0.78
Z27504791 0.869 0.828 7 0.87 0.83 0.86 0.82 0.83 0.73 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z27504791 T01
native IFP available
T01
selection_import_t01
0.887 1.000 0.677 native_similarity final_rank_score -26.2372 -0.920456 20 5 Pose
Z27504791 T02
native IFP available
T02
selection_import_t02
0.869 1.000 0.627 native_similarity final_rank_score -28.9942 -1.03621 17 5 Pose
Z27504791 T08
native IFP available
T08
selection_import_t08
0.860 1.000 0.599 native_similarity final_rank_score -31.6367 -1.23855 21 6 Pose
Z27504791 T06
native IFP available
T06
selection_import_t06
0.851 1.000 0.574 native_similarity final_rank_score -22.9905 -0.916212 18 7 Pose
Z27504791 T20
native IFP available
T20
selection_import_t20
0.851 1.000 0.574 native_similarity final_rank_score -21.2369 -0.740682 8 6 Pose
Z27504791 T05
native IFP available
T05
selection_import_t05
0.844 1.000 0.554 native_similarity final_rank_score -25.9211 -1.04839 16 9 Pose
Z27504791 T04
native IFP available
T04
selection_import_t04
0.834 1.000 0.525 native_similarity final_rank_score -23.4375 -0.946279 14 1 Pose
Z27504791 T14
native IFP available
T14
selection_import_t14
0.833 1.000 0.524 native_similarity final_rank_score -22.9041 -0.848421 16 7 Pose
Z27504791 T09
native IFP available
T09
selection_import_t09
0.820 1.000 0.485 native_similarity final_rank_score -27.2258 -1.03912 20 6 Pose
Z27504791 T15
native IFP available
T15
selection_import_t15
0.785 1.000 0.385 native_similarity final_rank_score -23.8677 -0.869779 11 7 Pose
Z27504791 T18
native IFP available
T18
selection_import_t18
0.780 1.000 0.373 native_similarity final_rank_score -23.0924 -0.778701 12 5 Pose
Z27504791 T17
native IFP available
T17
selection_import_t17
0.756 1.000 0.302 native_similarity final_rank_score -23.7986 -0.894262 17 9 Pose
Z27504791 T16
native IFP available
T16
selection_import_t16
0.731 1.000 0.230 native_similarity final_rank_score -25.1543 -0.809508 12 5 Pose