FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T14T16
Z237462396 0.863 0.794 3 0.86 0.79 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z237462396 T11
native IFP available
T11
selection_import_t11
0.863 1.000 0.609 native_similarity final_rank_score -22.0331 -0.996286 14 7 Pose
Z237462396 T14
native IFP available
T14
selection_import_t14
0.790 1.000 0.400 native_similarity final_rank_score -20.2217 -1.05947 13 7 Pose
Z237462396 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -22.2601 -1.00729 13 6 Pose