FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T04T05T06T08
Z16379965 0.858 0.834 6 0.81 0.85 0.81 0.86 0.83 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z16379965 T05
native IFP available
T05
selection_import_t05
0.858 1.000 0.595 native_similarity final_rank_score -26.9054 -1.10353 16 3 Pose
Z16379965 T03
native IFP available
T03
selection_import_t03
0.850 1.000 0.571 native_similarity final_rank_score -24.893 -1.03004 16 3 Pose
Z16379965 T08
native IFP available
T08
selection_import_t08
0.845 1.000 0.557 native_similarity final_rank_score -33.4222 -1.23452 16 2 Pose
Z16379965 T06
native IFP available
T06
selection_import_t06
0.825 1.000 0.500 native_similarity final_rank_score -21.1257 -0.91303 17 2 Pose
Z16379965 T04
native IFP available
T04
selection_import_t04
0.813 1.000 0.465 native_similarity final_rank_score -25.1506 -1.00414 11 2 Pose
Z16379965 T01
native IFP available
T01
selection_import_t01
0.812 1.000 0.462 native_similarity final_rank_score -25.1023 -0.985425 16 3 Pose