FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T11T18T20
Z13863770 0.816 0.816 1 0.82
Z13863770 0.793 0.770 3 0.76 0.76 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z13863770 T11
native IFP available
T11
selection_import_t11
0.816 1.000 0.474 native_similarity final_rank_score -22.1617 -0.847113 17 2 Pose
Z13863770 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -19.6502 -0.694836 6 5 Pose
Z13863770 T18
native IFP available
T18
selection_import_t18
0.761 1.000 0.317 native_similarity final_rank_score -19.7758 -0.75505 12 3 Pose
Z13863770 T01
native IFP available
T01
selection_import_t01
0.756 1.000 0.303 native_similarity final_rank_score -26.621 -0.9301 14 2 Pose