FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T04T06T16
Z112483722 0.836 0.796 3 0.82 0.84 0.73
Z112483722 0.800 0.800 1 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z112483722 T06
native IFP available
T06
selection_import_t06
0.836 1.000 0.532 native_similarity final_rank_score -19.3855 -0.885994 18 2 Pose
Z112483722 T02
native IFP available
T02
selection_import_t02
0.823 1.000 0.493 native_similarity final_rank_score -26.4115 -1.04695 17 5 Pose
Z112483722 T04
native IFP available
T04
selection_import_t04
0.800 1.000 0.428 native_similarity final_rank_score -21.8354 -0.947407 10 2 Pose
Z112483722 T16
native IFP available
T16
selection_import_t16
0.729 1.000 0.225 native_similarity final_rank_score -19.8165 -0.981155 13 7 Pose