FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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3 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T11T13T14T22
TC89 0.905 0.905 1 0.91
TC89 0.851 0.820 3 0.77 0.84 0.85
TC89 0.834 0.821 2 0.83 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC89 T22
native IFP available
T22
selection_import_t22
0.905 1.000 0.730 native_similarity final_rank_score -34.1649 -1.03286 25 9 Pose
TC89 T13
native IFP available
T13
selection_import_t13
0.851 1.000 0.574 native_similarity final_rank_score -30.2554 -0.94179 20 9 Pose
TC89 T11
native IFP available
T11
selection_import_t11
0.836 1.000 0.530 native_similarity final_rank_score -26.4674 -0.767728 18 6 Pose
TC89 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -28.1356 -0.868873 18 6 Pose
TC89 T14
native IFP available
T14
selection_import_t14
0.808 1.000 0.450 native_similarity final_rank_score -26.1072 -0.746106 16 7 Pose
TC89 T02
native IFP available
T02
selection_import_t02
0.775 1.000 0.356 native_similarity final_rank_score -21.5305 -0.831146 17 4 Pose