FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 13 best compound-target hits listed 13 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T07T09T10T11T12T14T15T17T18T20T21
TC288 0.953 0.848 5 0.79 0.94 0.95 0.80 0.76
TC288 0.920 0.840 8 0.85 0.80 0.83 0.84 0.81 0.79 0.88 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC288 T12
native IFP available
T12
selection_import_t12
0.953 1.000 0.866 native_similarity final_rank_score -29.2219 -1.09409 15 13 Pose
TC288 T10
native IFP available
T10
selection_import_t10
0.941 1.000 0.832 native_similarity final_rank_score -23.9679 -0.98822 18 11 Pose
TC288 T21
native IFP available
T21
selection_import_t21
0.920 1.000 0.771 native_similarity final_rank_score -22.9683 -0.991925 16 9 Pose
TC288 T20
native IFP available
T20
selection_import_t20
0.884 1.000 0.669 native_similarity final_rank_score -16.8303 -0.650588 8 9 Pose
TC288 T02
native IFP available
T02
selection_import_t02
0.846 1.000 0.560 native_similarity final_rank_score -21.6363 -0.872809 15 3 Pose
TC288 T11
native IFP available
T11
selection_import_t11
0.844 1.000 0.553 native_similarity final_rank_score -22.7766 -0.942304 18 4 Pose
TC288 T07
native IFP available
T07
selection_import_t07
0.834 1.000 0.525 native_similarity final_rank_score -29.8084 -1.15972 11 9 Pose
TC288 T15
native IFP available
T15
selection_import_t15
0.809 1.000 0.453 native_similarity final_rank_score -22.735 -0.869801 15 5 Pose
TC288 T14
native IFP available
T14
selection_import_t14
0.800 1.000 0.428 native_similarity final_rank_score -19.7092 -0.877709 10 8 Pose
TC288 T03
native IFP available
T03
selection_import_t03
0.796 1.000 0.416 native_similarity final_rank_score -23.3822 -0.981241 14 6 Pose
TC288 T09
native IFP available
T09
selection_import_t09
0.788 1.000 0.394 native_similarity final_rank_score -26.0553 -0.985093 17 4 Pose
TC288 T18
native IFP available
T18
selection_import_t18
0.786 1.000 0.388 native_similarity final_rank_score -17.1299 -0.721223 16 8 Pose
TC288 T17
native IFP available
T17
selection_import_t17
0.758 1.000 0.308 native_similarity final_rank_score -20.3889 -0.855509 16 5 Pose