FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T07T09T10
OHD_DCM_34 0.868 0.816 4 0.82 0.80 0.77 0.87

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_DCM_34 T10
native IFP available
T10
selection_import_t10
0.868 1.000 0.622 native_similarity final_rank_score -26.2088 -1.24314 15 7 Pose
OHD_DCM_34 T06
native IFP available
T06
selection_import_t06
0.825 1.000 0.500 native_similarity final_rank_score -25.2099 -1.08142 15 1 Pose
OHD_DCM_34 T07
native IFP available
T07
selection_import_t07
0.799 1.000 0.425 native_similarity final_rank_score -34.1249 -1.51476 15 3 Pose
OHD_DCM_34 T09
native IFP available
T09
selection_import_t09
0.774 1.000 0.353 native_similarity final_rank_score -26.6973 -1.28565 14 8 Pose