FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T09T15T16T18
OHD_ACDS_45 0.914 0.855 6 0.89 0.91 0.88 0.81 0.82 0.82

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_ACDS_45 T02
native IFP available
T02
selection_import_t02
0.914 1.000 0.753 native_similarity final_rank_score -24.1106 -0.900631 19 3 Pose
OHD_ACDS_45 T01
native IFP available
T01
selection_import_t01
0.893 1.000 0.693 native_similarity final_rank_score -23.9855 -0.881443 19 2 Pose
OHD_ACDS_45 T09
native IFP available
T09
selection_import_t09
0.878 1.000 0.652 native_similarity final_rank_score -23.4063 -0.894442 18 2 Pose
OHD_ACDS_45 T18
native IFP available
T18
selection_import_t18
0.820 1.000 0.485 native_similarity final_rank_score -16.6119 -0.697208 9 3 Pose
OHD_ACDS_45 T16
native IFP available
T16
selection_import_t16
0.815 1.000 0.472 native_similarity final_rank_score -22.0152 -0.777686 16 2 Pose
OHD_ACDS_45 T15
native IFP available
T15
selection_import_t15
0.813 1.000 0.466 native_similarity final_rank_score -20.4876 -0.894359 14 4 Pose