FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T06T09T13T16T17T19T20
KB_HAT_48 0.935 0.884 4 0.93 0.89 0.82 0.90
KB_HAT_48 0.848 0.785 5 0.83 0.73 0.76 0.75 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
KB_HAT_48 T01
native IFP available
T01
selection_import_t01
0.935 1.000 0.813 native_similarity final_rank_score -23.9739 -0.956667 19 9 Pose
KB_HAT_48 T09
native IFP available
T09
selection_import_t09
0.896 1.000 0.702 native_similarity final_rank_score -21.6892 -0.96092 18 8 Pose
KB_HAT_48 T02
native IFP available
T02
selection_import_t02
0.890 1.000 0.687 native_similarity final_rank_score -23.7054 -1.02465 18 6 Pose
KB_HAT_48 T20
native IFP available
T20
selection_import_t20
0.848 1.000 0.564 native_similarity final_rank_score -15.4524 -0.71141 10 7 Pose
KB_HAT_48 T13
native IFP available
T13
selection_import_t13
0.835 1.000 0.527 native_similarity final_rank_score -21.37 -1.0614 16 8 Pose
KB_HAT_48 T06
native IFP available
T06
selection_import_t06
0.816 1.000 0.475 native_similarity final_rank_score -19.0266 -0.880775 17 1 Pose
KB_HAT_48 T17
native IFP available
T17
selection_import_t17
0.758 1.000 0.308 native_similarity final_rank_score -15.3685 -0.897078 16 5 Pose
KB_HAT_48 T19
native IFP available
T19
selection_import_t19
0.752 1.000 0.293 native_similarity final_rank_score -25.5241 -1.21859 23 5 Pose
KB_HAT_48 T16
native IFP available
T16
selection_import_t16
0.731 1.000 0.230 native_similarity final_rank_score -23.2545 -1.07125 12 5 Pose