FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T07T08
KB_HAT_102 0.856 0.851 3 0.85 0.85 0.86

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
KB_HAT_102 T08
native IFP available
T08
selection_import_t08
0.856 1.000 0.588 native_similarity final_rank_score -30.7475 -1.18968 15 6 Pose
KB_HAT_102 T06
native IFP available
T06
selection_import_t06
0.851 1.000 0.575 native_similarity final_rank_score -12.0007 -0.902771 17 5 Pose
KB_HAT_102 T07
native IFP available
T07
selection_import_t07
0.846 1.000 0.561 native_similarity final_rank_score -29.0288 -1.11485 15 5 Pose