FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T21
Z57329641
[H]N(/N=C/c1ccc(O)c(OC)c1)C(=O)c1cc(C2CC2)nn1[H]
0.903 0.852 2 0.80 0.90

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57329641
[H]N(/N=C/c1ccc(O)c(OC)c1)C(=O)c1cc(C2CC2)nn1[H]
T21
native IFP available
T21
dockmulti_91311c650f2e_T21
0.903 1.000 0.723 native_similarity final_rank_score -17.6043 -0.837462 16 9 Pose
Z57329641
[H]N(/N=C/c1ccc(O)c(OC)c1)C(=O)c1cc(C2CC2)nn1[H]
T04
native IFP available
T04
dockmulti_91311c650f2e_T04
0.800 1.000 0.428 native_similarity final_rank_score -16.6457 -0.967328 10 1 Pose