FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T10
Z56792679
COc1ccc(/C=N/Nc2nc3ccccc3o2)cc1O
0.947 0.947 1 0.95
Z56792679
[H]Oc1cc(/C=N\Nc2nc3ccccc3o2)ccc1OC
0.787 0.787 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56792679
COc1ccc(/C=N/Nc2nc3ccccc3o2)cc1O
T10
native IFP available
T10
dockmulti_91311c650f2e_T10
0.947 1.000 0.850 native_similarity final_rank_score -18.7684 -1.00311 16 10 Pose
Z56792679
[H]Oc1cc(/C=N\Nc2nc3ccccc3o2)ccc1OC
T04
native IFP available
T04
dockmulti_91311c650f2e_T04
0.787 1.000 0.392 native_similarity final_rank_score -12.0373 -0.930363 9 2 Pose