FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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3 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T11T14T21
Z56785135
[H]Oc1ccc(/C=C2\N=C3CCCCCN3C2=O)cc1O[H]
0.912 0.912 1 0.91
Z56785135
[H]OC1=C/C(=C\c2nc3n(c2O)CCCCC3)C=CC1=O
0.909 0.909 1 0.91
Z56785135
[H]Oc1ccc(/C=C2/N=C3CCCCCN3C2=O)cc1O[H]
0.895 0.828 2 0.90 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56785135
[H]Oc1ccc(/C=C2\N=C3CCCCCN3C2=O)cc1O[H]
T21
native IFP available
T21
dockmulti_91311c650f2e_T21
0.912 1.000 0.748 native_similarity final_rank_score -23.1291 -1.13956 15 10 Pose
Z56785135
[H]OC1=C/C(=C\c2nc3n(c2O)CCCCC3)C=CC1=O
T10
native IFP available
T10
dockmulti_91311c650f2e_T10
0.909 1.000 0.740 native_similarity final_rank_score -16.6636 -1.20146 14 9 Pose
Z56785135
[H]Oc1ccc(/C=C2/N=C3CCCCCN3C2=O)cc1O[H]
T11
native IFP available
T11
dockmulti_91311c650f2e_T11
0.895 1.000 0.701 native_similarity final_rank_score -21.0481 -1.07697 13 5 Pose
Z56785135
[H]Oc1ccc(/C=C2/N=C3CCCCCN3C2=O)cc1O[H]
T14
native IFP available
T14
dockmulti_91311c650f2e_T14
0.760 1.000 0.315 native_similarity final_rank_score -17.3951 -0.914567 11 5 Pose