FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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4 compounds in matrix 18 best compound-target hits listed 18 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T07T08T09T10T11T12T13T14T15T16T18T19T20T22
Z56784540 0.929 0.833 5 0.81 0.86 0.83 0.75 0.93
Z56784540 0.895 0.815 4 0.84 0.78 0.90 0.74
Z56784540 0.858 0.838 2 0.82 0.86
Z56784540 0.843 0.818 7 0.81 0.81 0.84 0.82 0.84 0.81 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56784540 T20
native IFP available
T20
selection_import_t20
0.929 1.000 0.796 native_similarity final_rank_score -17.8316 -0.590921 11 6 Pose
Z56784540 T11
native IFP available
T11
selection_import_t11
0.895 1.000 0.701 native_similarity final_rank_score -23.2377 -0.729848 13 5 Pose
Z56784540 T22
native IFP available
T22
selection_import_t22
0.858 1.000 0.595 native_similarity final_rank_score -35.3345 -1.00164 24 9 Pose
Z56784540 T10
native IFP available
T10
selection_import_t10
0.856 1.000 0.588 native_similarity final_rank_score -28.347 -0.885953 15 16 Pose
Z56784540 T12
native IFP available
T12
selection_import_t12
0.843 1.000 0.551 native_similarity final_rank_score -28.0387 -0.786401 13 9 Pose
Z56784540 T03
native IFP available
T03
selection_import_t03
0.841 1.000 0.546 native_similarity final_rank_score -29.4261 -0.956391 18 2 Pose
Z56784540 T05
native IFP available
T05
selection_import_t05
0.836 1.000 0.532 native_similarity final_rank_score -24.1557 -0.825589 13 5 Pose
Z56784540 T14
native IFP available
T14
selection_import_t14
0.829 1.000 0.512 native_similarity final_rank_score -23.3603 -0.644737 11 6 Pose
Z56784540 T07
native IFP available
T07
selection_import_t07
0.821 1.000 0.488 native_similarity final_rank_score -29.5206 -0.946124 16 0 Pose
Z56784540 T13
native IFP available
T13
selection_import_t13
0.819 1.000 0.481 native_similarity final_rank_score -24.1336 -0.82773 18 4 Pose
Z56784540 T01
native IFP available
T01
selection_import_t01
0.809 1.000 0.454 native_similarity final_rank_score -28.1392 -0.872194 19 4 Pose
Z56784540 T02
native IFP available
T02
selection_import_t02
0.809 1.000 0.454 native_similarity final_rank_score -28.1667 -0.88379 19 2 Pose
Z56784540 T15
native IFP available
T15
selection_import_t15
0.809 1.000 0.453 native_similarity final_rank_score -29.2608 -0.805989 15 7 Pose
Z56784540 T08
native IFP available
T08
selection_import_t08
0.805 1.000 0.443 native_similarity final_rank_score -31.8198 -0.986887 13 2 Pose
Z56784540 T18
native IFP available
T18
selection_import_t18
0.797 1.000 0.419 native_similarity final_rank_score -25.5863 -0.624245 13 7 Pose
Z56784540 T09
native IFP available
T09
selection_import_t09
0.782 1.000 0.376 native_similarity final_rank_score -20.9854 -0.826977 16 4 Pose
Z56784540 T19
native IFP available
T19
selection_import_t19
0.747 1.000 0.276 native_similarity final_rank_score -33.0857 -0.99912 20 8 Pose
Z56784540 T16
native IFP available
T16
selection_import_t16
0.743 1.000 0.264 native_similarity final_rank_score -25.7631 -0.680997 15 4 Pose