FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T06T07T08T10T14T18T19T20T21T22
Z49724509 0.935 0.850 6 0.93 0.75 0.75 0.90 0.93 0.84
Z49724509 0.872 0.795 5 0.76 0.79 0.87 0.80 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49724509 T10
native IFP available
T10
selection_import_t10
0.935 1.000 0.813 native_similarity final_rank_score -31.2552 -1.45598 16 12 Pose
Z49724509 T21
native IFP available
T21
selection_import_t21
0.926 1.000 0.790 native_similarity final_rank_score -24.2338 -1.14598 15 7 Pose
Z49724509 T20
native IFP available
T20
selection_import_t20
0.898 1.000 0.710 native_similarity final_rank_score -17.3361 -0.815124 11 7 Pose
Z49724509 T07
native IFP available
T07
selection_import_t07
0.872 1.000 0.634 native_similarity final_rank_score -32.2253 -1.39302 19 6 Pose
Z49724509 T22
native IFP available
T22
selection_import_t22
0.841 1.000 0.545 native_similarity final_rank_score -28.0042 -1.29827 19 14 Pose
Z49724509 T08
native IFP available
T08
selection_import_t08
0.796 1.000 0.418 native_similarity final_rank_score -29.6607 -1.35339 10 9 Pose
Z49724509 T06
native IFP available
T06
selection_import_t06
0.791 1.000 0.402 native_similarity final_rank_score -25.18 -0.990568 16 3 Pose
Z49724509 T03
native IFP available
T03
selection_import_t03
0.760 1.000 0.313 native_similarity final_rank_score -24.7218 -1.12173 12 9 Pose
Z49724509 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -26.6197 -0.950209 13 7 Pose
Z49724509 T14
native IFP available
T14
selection_import_t14
0.751 1.000 0.289 native_similarity final_rank_score -22.6703 -0.930807 13 10 Pose
Z49724509 T19
native IFP available
T19
selection_import_t19
0.748 1.000 0.281 native_similarity final_rank_score -32.1781 -1.30146 13 7 Pose