FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 17 best compound-target hits listed 17 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T05T08T09T10T11T12T14T15T16T17T18T19T20T21T22
Z49638306 0.939 0.838 9 0.91 0.75 0.83 0.84 0.77 0.85 0.87 0.79 0.94
Z49638306 0.924 0.815 8 0.92 0.79 0.73 0.74 0.77 0.75 0.89 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49638306 T22
native IFP available
T22
selection_import_t22
0.939 1.000 0.824 native_similarity final_rank_score -31.2989 -1.15112 22 12 Pose
Z49638306 T10
native IFP available
T10
selection_import_t10
0.924 1.000 0.783 native_similarity final_rank_score -31.267 -1.07037 18 12 Pose
Z49638306 T21
native IFP available
T21
selection_import_t21
0.915 1.000 0.758 native_similarity final_rank_score -34.63 -0.980801 16 7 Pose
Z49638306 T02
native IFP available
T02
selection_import_t02
0.911 1.000 0.747 native_similarity final_rank_score -21.9565 -0.910572 18 8 Pose
Z49638306 T20
native IFP available
T20
selection_import_t20
0.894 1.000 0.696 native_similarity final_rank_score -25.3759 -0.756591 12 10 Pose
Z49638306 T12
native IFP available
T12
selection_import_t12
0.866 1.000 0.617 native_similarity final_rank_score -25.6236 -0.904324 20 8 Pose
Z49638306 T11
native IFP available
T11
selection_import_t11
0.850 1.000 0.570 native_similarity final_rank_score -21.6784 -0.794952 14 7 Pose
Z49638306 T08
native IFP available
T08
selection_import_t08
0.844 1.000 0.554 native_similarity final_rank_score -37.7354 -1.21986 14 9 Pose
Z49638306 T05
native IFP available
T05
selection_import_t05
0.830 1.000 0.514 native_similarity final_rank_score -32.6909 -0.94378 12 6 Pose
Z49638306 T14
native IFP available
T14
selection_import_t14
0.790 1.000 0.400 native_similarity final_rank_score -26.3523 -0.780324 13 4 Pose
Z49638306 T18
native IFP available
T18
selection_import_t18
0.789 1.000 0.397 native_similarity final_rank_score -21.2671 -0.71915 15 8 Pose
Z49638306 T17
native IFP available
T17
selection_import_t17
0.771 1.000 0.345 native_similarity final_rank_score -24.3755 -0.799974 18 4 Pose
Z49638306 T09
native IFP available
T09
selection_import_t09
0.765 1.000 0.329 native_similarity final_rank_score -31.2835 -0.974088 12 7 Pose
Z49638306 T19
native IFP available
T19
selection_import_t19
0.755 1.000 0.300 native_similarity final_rank_score -37.6676 -1.0501 20 7 Pose
Z49638306 T03
native IFP available
T03
selection_import_t03
0.747 1.000 0.277 native_similarity final_rank_score -32.5822 -1.07455 12 7 Pose
Z49638306 T16
native IFP available
T16
selection_import_t16
0.745 1.000 0.270 native_similarity final_rank_score -27.6702 -0.865923 14 5 Pose
Z49638306 T15
native IFP available
T15
selection_import_t15
0.727 1.000 0.221 native_similarity final_rank_score -23.4452 -0.794232 11 7 Pose