FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T14T21
Z46095146
[H]Oc1ccc(/C=C2\COc3ccccc3C2=O)cc1O[H]
0.908 0.908 1 0.91
Z46095146
[H]Oc1ccc(/C=C2/COc3ccccc3C2=O)cc1O[H]
0.804 0.804 1 0.80

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z46095146
[H]Oc1ccc(/C=C2\COc3ccccc3C2=O)cc1O[H]
T21
native IFP available
T21
selection_import_t21
0.908 1.000 0.736 native_similarity final_rank_score -23.0481 -1.22981 16 7 Pose
Z46095146
[H]Oc1ccc(/C=C2/COc3ccccc3C2=O)cc1O[H]
T14
native IFP available
T14
selection_import_t14
0.804 1.000 0.440 native_similarity final_rank_score -19.7393 -1.2978 12 6 Pose