FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 21 best compound-target hits listed 21 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T04T05T06T07T08T09T10T11T12T14T15T16T17T18T19T20T21T22
Z44847963 0.934 0.851 4 0.79 0.93 0.88 0.80
Z44847963 0.914 0.827 17 0.83 0.83 0.76 0.85 0.79 0.89 0.90 0.79 0.89 0.77 0.78 0.79 0.80 0.75 0.85 0.91 0.87

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44847963 T10
native IFP available
T10
selection_import_t10
0.934 1.000 0.813 native_similarity final_rank_score -30.1181 -0.952839 20 12 Pose
Z44847963 T21
native IFP available
T21
selection_import_t21
0.914 1.000 0.755 native_similarity final_rank_score -25.6886 -0.798773 15 8 Pose
Z44847963 T08
native IFP available
T08
selection_import_t08
0.896 1.000 0.703 native_similarity final_rank_score -33.3892 -1.05901 17 7 Pose
Z44847963 T11
native IFP available
T11
selection_import_t11
0.894 1.000 0.698 native_similarity final_rank_score -30.3793 -0.997616 15 6 Pose
Z44847963 T07
native IFP available
T07
selection_import_t07
0.889 1.000 0.682 native_similarity final_rank_score -35.0127 -1.09943 16 9 Pose
Z44847963 T12
native IFP available
T12
selection_import_t12
0.882 1.000 0.664 native_similarity final_rank_score -23.145 -0.917764 16 6 Pose
Z44847963 T22
native IFP available
T22
selection_import_t22
0.872 1.000 0.634 native_similarity final_rank_score -30.8753 -1.06966 29 11 Pose
Z44847963 T05
native IFP available
T05
selection_import_t05
0.853 1.000 0.579 native_similarity final_rank_score -22.1691 -0.930582 11 7 Pose
Z44847963 T20
native IFP available
T20
selection_import_t20
0.851 1.000 0.573 native_similarity final_rank_score -23.5686 -0.824135 9 7 Pose
Z44847963 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -31.1212 -0.896059 18 6 Pose
Z44847963 T02
native IFP available
T02
selection_import_t02
0.834 1.000 0.524 native_similarity final_rank_score -35.2818 -0.947142 18 6 Pose
Z44847963 T15
native IFP available
T15
selection_import_t15
0.797 1.000 0.421 native_similarity final_rank_score -20.6308 -0.827772 18 5 Pose
Z44847963 T18
native IFP available
T18
selection_import_t18
0.797 1.000 0.419 native_similarity final_rank_score -21.158 -0.713014 13 3 Pose
Z44847963 T17
native IFP available
T17
selection_import_t17
0.792 1.000 0.405 native_similarity final_rank_score -25.6577 -0.862379 17 7 Pose
Z44847963 T04
native IFP available
T04
selection_import_t04
0.792 1.000 0.405 native_similarity final_rank_score -23.397 -0.892234 15 9 Pose
Z44847963 T06
native IFP available
T06
selection_import_t06
0.788 1.000 0.394 native_similarity final_rank_score -24.9974 -0.737507 17 1 Pose
Z44847963 T09
native IFP available
T09
selection_import_t09
0.785 1.000 0.386 native_similarity final_rank_score -22.5547 -0.919152 18 4 Pose
Z44847963 T16
native IFP available
T16
selection_import_t16
0.782 1.000 0.378 native_similarity final_rank_score -25.1003 -0.750125 14 6 Pose
Z44847963 T14
native IFP available
T14
selection_import_t14
0.772 1.000 0.348 native_similarity final_rank_score -22.0757 -0.767574 18 6 Pose
Z44847963 T03
native IFP available
T03
selection_import_t03
0.765 1.000 0.328 native_similarity final_rank_score -30.5149 -0.998852 16 7 Pose
Z44847963 T19
native IFP available
T19
selection_import_t19
0.750 1.000 0.286 native_similarity final_rank_score -27.4665 -1.03765 11 7 Pose