FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T08T12T15T16
Z30217254 0.905 0.810 3 0.81 0.90 0.71
Z30217254 0.809 0.797 2 0.81 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30217254 T12
native IFP available
T12
selection_import_t12
0.905 1.000 0.727 native_similarity final_rank_score -26.09 -1.0486 16 10 Pose
Z30217254 T08
native IFP available
T08
selection_import_t08
0.813 1.000 0.465 native_similarity final_rank_score -33.2821 -1.19806 15 7 Pose
Z30217254 T04
native IFP available
T04
selection_import_t04
0.809 1.000 0.454 native_similarity final_rank_score -25.5819 -0.970959 12 5 Pose
Z30217254 T15
native IFP available
T15
selection_import_t15
0.786 1.000 0.388 native_similarity final_rank_score -23.8786 -0.875255 16 7 Pose
Z30217254 T16
native IFP available
T16
selection_import_t16
0.713 1.000 0.180 native_similarity final_rank_score -22.0097 -0.821522 12 4 Pose