FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T09T15
Z29395256
[H]N(C(=O)c1ccccc1)[C@@H](CCSC)c1nc2ccccc2n1[H]
0.827 0.822 2 0.83 0.82
Z29395256
[H]N(C(=O)c1ccccc1)[C@H](CCSC)c1nc2ccccc2n1[H]
0.789 0.789 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z29395256
[H]N(C(=O)c1ccccc1)[C@@H](CCSC)c1nc2ccccc2n1[H]
T06
native IFP available
T06
dockmulti_91311c650f2e_T06
0.827 1.000 0.507 native_similarity final_rank_score -19.0481 -0.928922 18 1 Pose
Z29395256
[H]N(C(=O)c1ccccc1)[C@@H](CCSC)c1nc2ccccc2n1[H]
T09
native IFP available
T09
dockmulti_91311c650f2e_T09
0.816 1.000 0.474 native_similarity final_rank_score -22.5004 -1.06631 18 3 Pose
Z29395256
[H]N(C(=O)c1ccccc1)[C@H](CCSC)c1nc2ccccc2n1[H]
T15
native IFP available
T15
dockmulti_91311c650f2e_T15
0.789 1.000 0.397 native_similarity final_rank_score -25.1383 -1.06571 15 3 Pose