FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T19
Z28139254
[H]N(C(=O)/C=C/c1cn(-c2ccccc2)nc1-c1ccc(Br)cc1)c1ccc(OC)cc1
0.858 0.858 1 0.86
Z28139254
[H]N(C(=O)/C=C\c1cn(-c2ccccc2)nc1-c1ccc(Br)cc1)c1ccc(OC)cc1
0.687 0.687 1 0.69

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z28139254
[H]N(C(=O)/C=C/c1cn(-c2ccccc2)nc1-c1ccc(Br)cc1)c1ccc(OC)cc1
T11
native IFP available
T11
dockmulti_91311c650f2e_T11
0.858 1.000 0.593 native_similarity final_rank_score -15.7348 -0.616815 15 3 Pose
Z28139254
[H]N(C(=O)/C=C\c1cn(-c2ccccc2)nc1-c1ccc(Br)cc1)c1ccc(OC)cc1
T19
native IFP available
T19
dockmulti_91311c650f2e_T19
0.687 1.000 0.104 native_similarity final_rank_score -24.1099 -0.815393 19 1 Pose