FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T11T12T17
Z24181579 0.884 0.832 3 0.84 0.88 0.77
Z24181579 0.831 0.806 2 0.78 0.83

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z24181579 T12
native IFP available
T12
selection_import_t12
0.884 1.000 0.667 native_similarity final_rank_score -26.1742 -0.82401 16 12 Pose
Z24181579 T03
native IFP available
T03
selection_import_t03
0.838 1.000 0.537 native_similarity final_rank_score -29.9961 -0.963317 15 4 Pose
Z24181579 T11
native IFP available
T11
selection_import_t11
0.831 1.000 0.518 native_similarity final_rank_score -19.1531 -0.733148 17 4 Pose
Z24181579 T01
native IFP available
T01
selection_import_t01
0.780 1.000 0.371 native_similarity final_rank_score -21.2704 -0.777819 15 5 Pose
Z24181579 T17
native IFP available
T17
selection_import_t17
0.773 1.000 0.352 native_similarity final_rank_score -26.6302 -0.783773 17 4 Pose