FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T05T06T08T09T11T18T20
Z16042352 0.890 0.819 3 0.78 0.89 0.79
Z16042352 0.869 0.808 5 0.79 0.87 0.78 0.85 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z16042352 T11
native IFP available
T11
selection_import_t11
0.890 1.000 0.685 native_similarity final_rank_score -28.3647 -1.37062 14 6 Pose
Z16042352 T05
native IFP available
T05
selection_import_t05
0.869 1.000 0.624 native_similarity final_rank_score -27.8518 -1.25225 14 6 Pose
Z16042352 T08
native IFP available
T08
selection_import_t08
0.846 1.000 0.559 native_similarity final_rank_score -31.4012 -1.3976 13 3 Pose
Z16042352 T04
native IFP available
T04
selection_import_t04
0.792 1.000 0.405 native_similarity final_rank_score -23.1628 -1.08049 11 2 Pose
Z16042352 T20
native IFP available
T20
selection_import_t20
0.786 1.000 0.388 native_similarity final_rank_score -18.4095 -0.819619 7 6 Pose
Z16042352 T09
native IFP available
T09
selection_import_t09
0.782 1.000 0.376 native_similarity final_rank_score -24.4647 -1.11827 16 5 Pose
Z16042352 T06
native IFP available
T06
selection_import_t06
0.780 1.000 0.371 native_similarity final_rank_score -22.9104 -1.07115 15 1 Pose
Z16042352 T18
native IFP available
T18
selection_import_t18
0.756 1.000 0.302 native_similarity final_rank_score -18.0427 -0.895232 14 7 Pose