FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T15
TC485
[H]O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@]23CC=C(Cn2cc(C[N+]([H])(C)C)nn2)CO3)C1
0.817 0.817 1 0.82
TC485
[H]O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@]23CC=C(Cn2cc(CN(C)C)nn2)CO3)C1
0.809 0.809 1 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC485
[H]O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@]23CC=C(Cn2cc(C[N+]([H])(C)C)nn2)CO3)C1
T04
native IFP available
T04
dockmulti_91311c650f2e_T04
0.817 1.000 0.478 native_similarity final_rank_score -25.7598 -0.71239 14 1 Pose
TC485
[H]O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@@]2(C)[C@H]3CC[C@@]23CC=C(Cn2cc(CN(C)C)nn2)CO3)C1
T15
native IFP available
T15
dockmulti_91311c650f2e_T15
0.809 1.000 0.453 native_similarity final_rank_score -23.1238 -0.648092 15 3 Pose