FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T07T08T14
TC393 0.848 0.829 3 0.85 0.83 0.80
TC393 0.837 0.837 1 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC393 T01
native IFP available
T01
selection_import_t01
0.848 1.000 0.567 native_similarity final_rank_score -24.452 -0.811521 18 3 Pose
TC393 T08
native IFP available
T08
selection_import_t08
0.837 1.000 0.536 native_similarity final_rank_score -31.3856 -0.999045 17 6 Pose
TC393 T07
native IFP available
T07
selection_import_t07
0.834 1.000 0.525 native_similarity final_rank_score -33.74 -1.13913 18 5 Pose
TC393 T14
native IFP available
T14
selection_import_t14
0.804 1.000 0.440 native_similarity final_rank_score -18.8448 -0.691264 13 4 Pose