FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T14
OHD_TC1_33
[H]Oc1c(CC=C(C)C)cc2c(=O)ccoc2c1O[H]
0.829 0.799 2 0.83 0.77

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
OHD_TC1_33
[H]Oc1c(CC=C(C)C)cc2c(=O)ccoc2c1O[H]
T06
native IFP available
T06
selection_import_t06
0.829 1.000 0.512 native_similarity final_rank_score -19.0277 -1.26191 16 5 Pose
OHD_TC1_33
[H]Oc1c(CC=C(C)C)cc2c(=O)ccoc2c1O[H]
T14
native IFP available
T14
selection_import_t14
0.769 1.000 0.340 native_similarity final_rank_score -19.9045 -1.39659 12 6 Pose