FAIRMol

OHD_MAC_43

Pose ID 9957 Pose 471

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T15
T. brucei TR (Dimer cleft site) T. brucei Dimer cleft site
Ligand OHD_MAC_43
PDB9IFF

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak Metrics pending
Promising but geometrically suspicious
Binding strong Geometry low Native strong SASA pending
Strain ΔE
50.8 kcal/mol
Protein clashes
6
Internal clashes
6
Native overlap
contact recall 0.69, Jaccard 0.45
Burial
85%
Reason: 6 internal clashes, strain 50.8 kcal/mol
strain ΔE 50.8 kcal/mol 6 protein-contact clashes 6 intramolecular clashes

Interaction summary

HB 11 HY 8 PI 0 CLASH 6

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

Final rank6.327Score-15.005
Inter norm-0.850Intra norm0.366
Top1000noExcludedyes
Contacts16H-bonds11
Artifact reasonexcluded; geometry warning; 15 clashes; 4 protein clashes; high strain Δ 50.8
Residues
ALA209 ALA244 ALA90 ARG74 ASN245 ASP71 GLY214 GLY215 GLY246 LYS211 LYS89 MET70 PRO212 PRO213 TYR408 VAL88

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name9IFFContacts13
PoseOpen native poseHB0
IFP residues
ALA209 ARG74 ASN208 GLY214 GLY215 GLY85 LEU73 LYS211 MET70 PHE83 PRO212 PRO213 VAL88
Current overlap9Native recall0.69
Jaccard0.45RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

Protein summary

489 residues
Protein targetT15Atoms7420
Residues489Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:264; MET:204

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
471 6.327012435134533 -0.849657 -15.0048 11 16 9 0.69 - - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
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