FAIRMol

OSA_Lib_312

Pose ID 5580 Pose 162

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T09
L. major DHFR-TS L. major
Ligand OSA_Lib_312

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak Metrics pending
Weak or marginal quality
Binding strong Geometry medium Native strong SASA pending
Strain ΔE
41.3 kcal/mol
Protein clashes
0
Internal clashes
0
Native overlap
contact recall 0.76, Jaccard 0.67, H-bond role recall 0.00
Burial
83%
Reason: no major geometry red flags detected

Interaction summary

HB 0 HY 24 PI 1 CLASH 0

HB · H-bonds

No hb · h-bonds detected for this pose.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

No clash · clashes detected for this pose.
Final rank2.438Score-25.153
Inter norm-0.572Intra norm0.048
Top1000noExcludedyes
Contacts19H-bonds0
Artifact reasonexcluded; hard geometry fail; 1 severe clash; high strain Δ 41.3
Residues
NDP301 ALA32 ARG48 ARG97 LEU94 LYS57 MET53 MET79 PHE56 PHE91 PRO50 PRO88 SER86 THR83 TYR162 VAL156 VAL30 VAL31 VAL87

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name3CL9Contacts21
PoseOpen native poseHB0
IFP residues
NDP301 ALA32 ARG97 ASP52 GLY157 ILE45 LEU94 LYS57 MET53 PHE55 PHE56 PHE91 PRO88 SER86 THR180 THR83 TYR162 VAL156 VAL30 VAL31 VAL87
Current overlap16Native recall0.76
Jaccard0.67RMSD-
HB strict0Strict recall0.00
HB same residue+role0HB role recall0.00
HB same residue0HB residue recall0.00

Protein summary

511 residues
Protein targetT09Atoms8170
Residues511Chains2
Residue summaryLEU:1064; ARG:840; LYS:572; GLU:570; VAL:528; PHE:460; ILE:456; ALA:440; PRO:420; THR:406; TYR:357; ASP:312; GLN:289; ASN:238; SER:231; GLY:224

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:NDP301

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
162 2.438359485152682 -0.571645 -25.1528 0 19 16 0.76 0.00 - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.