FAIRMol

Z49559005

Pose ID 12818 Pose 617

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T19
T. brucei TR (NADPH binding site) T. brucei NADPH binding site
Ligand Z49559005
PDB2WOV

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Promising Metrics pending
Promising but geometrically suspicious
Binding strong Geometry low Native weak SASA pending
Strain ΔE
not computed
Protein clashes
0
Internal clashes
8
Native overlap
contact recall 0.22, Jaccard 0.16, H-bond role recall 0.00
Burial
100%
Reason: 8 internal clashes
8 intramolecular clashes

Interaction summary

HB 6 HY 21 PI 1 CLASH 0

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

No clash · clashes detected for this pose.
Final rank4.549Score-29.429
Inter norm-1.210Intra norm0.078
Top1000noExcludedyes
Contacts17H-bonds6
Artifact reasonexcluded; geometry warning; 8 clashes; 4 protein clashes
Residues
CYS52 CYS57 GLU202 GLY56 ILE199 LEU334 LYS60 LYS61 NDP800 PHE182 PHE203 PHE367 PRO336 SER178 THR335 THR51 VAL55

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name2WOVContacts27
PoseOpen native poseHB0
IFP residues
ALA284 ALA365 ARG222 ARG228 ARG287 ASN223 ASN254 GLN165 GLU202 GLY195 GLY196 GLY197 GLY286 ILE199 ILE285 LEU227 LEU334 LYS60 MET333 NDP800 PHE198 PHE367 PRO167 SER200 TYR221 VAL194 VAL366
Current overlap6Native recall0.22
Jaccard0.16RMSD-
HB strict0Strict recall0.00
HB same residue+role0HB role recall0.00
HB same residue0HB residue recall0.00

Protein summary

493 residues
Protein targetT19Atoms7541
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:330; TYR:294; ASP:264; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
C:NDP800

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
617 4.54897629765818 -1.20994 -29.4287 6 17 6 0.22 0.00 - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.