FAIRMol

Z2588062695

Pose ID 12002 Pose 481

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T18
T. brucei TR (Mepacrine binding site (MBS, site 1)) T. brucei Mepacrine binding site (MBS, site 1)
Ligand Z2588062695
PDB6RB5

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak Metrics pending
Weak or marginal quality
Binding strong Geometry medium Native mixed SASA pending
Strain ΔE
36.8 kcal/mol
Protein clashes
4
Internal clashes
4
Native overlap
contact recall 0.46, Jaccard 0.30
Burial
75%
Reason: no major geometry red flags detected
4 protein-contact clashes 4 intramolecular clashes

Interaction summary

HB 10 HY 10 PI 0 CLASH 4

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

Final rank4.127Score-19.264
Inter norm-1.506Intra norm0.131
Top1000noExcludedyes
Contacts13H-bonds10
Artifact reasonexcluded; geometry warning; 1 clash; 4 protein clashes; high strain Δ 36.8
Residues
CYS52 FAD501 GLU18 GLY13 GLY49 GLY50 ILE339 LEU17 SER14 THR335 TYR110 VAL53 VAL58

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name6RB5Contacts13
PoseOpen native poseHB0
IFP residues
ASP116 GLU18 GLY112 ILE106 LEU17 MET113 SER109 THR117 THR335 TRP21 TYR110 VAL53 VAL58
Current overlap6Native recall0.46
Jaccard0.30RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

Protein summary

493 residues
Protein targetT18Atoms7550
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:276; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
481 4.127471781834639 -1.50647 -19.2636 10 13 6 0.46 - - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.