FAIRMol

Z1213671973

Pose ID 1133 Pose 455

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T02
Human DHFR Human
Ligand Z1213671973
PDB5SD8

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Promising Metrics pending
Promising but geometrically suspicious
Binding strong Geometry low Native strong SASA pending
Strain ΔE
not computed
Protein clashes
6
Internal clashes
6
Native overlap
contact recall 0.67, Jaccard 0.56, H-bond role recall 0.00
Burial
100%
Reason: 6 internal clashes
6 protein-contact clashes 6 intramolecular clashes

Interaction summary

HB 6 HY 24 PI 2 CLASH 6

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

Native π–π recall is disabled because no explicit native π–π reference was stored.

HY · Hydrophobic contacts

CLASH · Clashes

Final rank3.491Score-34.817
Inter norm-0.759Intra norm-0.265
Top1000noExcludedyes
Contacts18H-bonds6
Artifact reasonexcluded; hard geometry fail; 1 severe clash; 1 protein clash; 2 cofactor-context clashes
Residues
ALA10 ARG29 ASP22 GLU31 GLY21 ILE8 LEU23 LEU28 NAP201 PHE32 PHE35 PRO27 PRO62 SER60 THR137 TYR122 TYR34 VAL9

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name5SD8Contacts21
PoseOpen native poseHB0
IFP residues
ALA10 ASN65 ASP22 GLN36 GLU31 GLY117 GLY21 ILE61 ILE8 LEU23 LEU68 NAP201 PHE32 PHE35 PRO62 SER60 THR137 THR57 TYR122 VAL116 VAL9
Current overlap14Native recall0.67
Jaccard0.56RMSD-
HB strict0Strict recall0.00
HB same residue+role0HB role recall0.00
HB same residue0HB residue recall0.00

Protein summary

200 residues
Protein targetT02Atoms3128
Residues200Chains2
Residue summaryLYS:374; LEU:361; GLU:240; VAL:224; ARG:192; PHE:180; ILE:171; PRO:168; ASN:140; SER:132; TYR:126; GLN:119; ASP:108; MET:102; THR:98; GLY:91

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:NAP201

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
455 3.4912112785194473 -0.758744 -34.8173 6 18 14 0.67 0.00 - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.