FAIRMol

OSA_Lib_394

Pose ID 10462 Pose 297

DB fairmolDocking pose analysis is being read from this database.
Molecular metrics status: missing
Molecular metrics have not been computed yet for this pose.
No cached metrics
T16
T. brucei TR (Dimer interface (site 2)) T. brucei Dimer interface (site 2)
Ligand OSA_Lib_394
PDB6RB5

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Weak Metrics pending
Weak or marginal quality
Binding strong Geometry high Native strong SASA pending
Strain ΔE
20.8 kcal/mol
Protein clashes
2
Internal clashes
2
Native overlap
contact recall 0.75, Jaccard 0.53
Burial
80%
Reason: no major geometry red flags detected
2 protein-contact clashes

Interaction summary

HB 6 HY 24 PI 0 CLASH 2

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

Final rank5.452Score-28.116
Inter norm-0.966Intra norm-0.004
Top1000noExcludedyes
Contacts14H-bonds6
Artifact reasonexcluded; geometry warning; 12 clashes; 4 protein clashes; moderate strain Δ 20.8
Residues
ALA209 ALA90 ASN208 GLY85 LEU73 LYS211 LYS89 MET70 PRO187 PRO212 PRO213 SER86 TYR210 VAL88

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name6RB5Contacts12
PoseOpen native poseHB0
IFP residues
ALA90 ARG74 GLY85 LEU73 LYS89 MET70 PHE83 PRO212 PRO213 SER86 SER87 VAL88
Current overlap9Native recall0.75
Jaccard0.53RMSD-
HB strict0Strict recall-
HB same residue+role0HB role recall-
HB same residue0HB residue recall-

Protein summary

493 residues
Protein targetT16Atoms7551
Residues493Chains1
Residue summaryVAL:768; LYS:704; LEU:703; ILE:532; GLU:450; THR:434; ARG:408; PHE:400; ALA:390; ASN:350; PRO:350; GLY:336; SER:319; TYR:294; ASP:276; MET:221

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:FAD501

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
297 5.452228710232679 -0.96555 -28.1155 6 14 9 0.75 - - yes Current

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.